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	Chromatography of particulate containing materials with a NEW Process Column Design Proxcys, www.proxcys.com have introduced a column system "Axcis", scaleable from lab to manufacturing use with any process resin, which can operate with unclarified feed material without blocking the inlet screen. Tangential circulation of the load material keeps the screen clear whilst pressure allows normal load through the screen onto the packed bed. The design is compatible with any traditional resin and adsorption mode of operation. Columns are packed to high efficiency into a stable radial configuration. This offers additional advantages in terms of convenient scaleability and reduced footprint in manufacturing facilities. http://www.proxcys.nl/master_products.html PROXCYS Downstream Biosystems b.v. Kampweg 2 NL-7812BS Emmen The Netherlands Tel +31 591 677 447 Fax: +31 591 677 448 E-mail: info@proxcys.com	PROXCYS
	Solving scale-up and solubility challengesin liquid chromatography Dynamic Extractions announce a range of High Performance CCC systems that scale from analytical to kilo quantities. "Counter Current Chromatography" is in principle a very simple technique based on partitioning. This means it is predictable and reproducible. Separations of complex mixtures are achieved without the need for solid stationary phases which would not tolerate high levels solids or particulates in the crude injection. By using two liquid phases, one stationary the other mobile, products with low solubility can be processed and isolated to high purity. Due to the absence of a packed column Methods are developed at analytical scale (mgs) and can be directly scaled up to kilogram scale There is no packed bed to clean or validate. This powerful technique will tolerate the presence of cell debris and other particulate impurities, so feedstock clarification is not required! In principle this technique is possible with any mode which uses immiscible solvents, and is currently best suited to small molecules or peptides, rather than solvent sensitive products such as proteins etc. Any method using RPC or NPC can be adapted to this technique. For further information: http://www.dynamicextractions.com Email contact: David.Keay@dynamicextractions.com	Dynamic Extractions
	Aggregation reduced and product stability enhanced by NEW technology   NVoy Novexin’s proprietary NVoy technology offers substantial improvements in many aspects of bioproduct production and analysis. It can be used to maintain yield and improves recovery for proteins, viruses and other bioactive preparations. This unique polymer chemistry reduces protein aggregation and non-specific binding, enhances protein stability, maintaining proteins in solution at high concentration and avoiding the use of detergents. The technology also improves refold yield and refolded protein quality. The polymer is easily removed from proteins (by ion exchange, hydrophobic interaction or affinity chromatography) and is compatible with commonly used analytical techniques such as SDS-PAGE, mass spectrometry, circular dichroism and immunoassay. Novexin supplies a convenient kit for research purposes and can supply larger quantities of polymer for process applications. More Detail: http://www.novexin.com/technology/stabilisation.html Contact: info@novexin.com	Novexin
	New 10-Channel Parallel Protein Purification Workstation Presearch The new BioOptix™10 from Teledyne ISCO is a parallel protein purification system that can simultaneously purify up to ten samples at a time. If you are constrained by one-at-a-time sample purification, then this unique system has the potential to deliver up to a ten-fold increase in productivity. This purification system contains ten independent pumps that keep flow rates properly regulated in each channel, and ten independent UV detectors so that you can monitor the separation in every way. The software management system collects and stores information for each channel so that purified sample can be located in the fraction collector post run. This innovative system is also ideally suited to parallel resin screening and methods scouting applications. Key features include: Versatile column clamps provide quick, secure mounting for a range of columns from the smallest affinity sizes to larger gel permeation columns. The easy to use control software contains colour coded sample and fraction tracking to locate collected fractions and match to the chromatogram for each sample. Solvent delivery components are compatible with salt buffers as well as common organic solvents to ensure reliability and low maintenance. Individual sample introduction lines for each channel provide fast and easy sample loading without risk of cross-contamination. High fraction capacity - 20 to 60 fractions per sample. More Detail: http://www.presearch.co.uk/pages/products/show-product.asp?id=1515 Contact:      enquiries@presearch.co.uk Presearch Limited Unitech House Unit B1 - B2 Kingsland Business Park Basingstoke Hampshire RG24 8PZ United Kingdom Tel: +44 (0)1256 365492 Email: enquiries@presearch.co.uk Web:  www.presearch.co.uk	Presearch
	Peptide Selectivity Enhanced by Novel Stationary Phase Chemistry Astec Chirobiotic®T for peptide analysis Closely related peptides that are different from each other because of a particular single amino acid or because of the chirality of an amino acid either within the peptide or at its terminus are of great importance in drug discovery. Current LC analysis usually employs reversed phase (C18) methods which often need ion pairing reagents that modify the column and are not MS compatible, or ion exchange LC that uses buffers that are also generally not MS compatible. LC/MS compatibility and improved alternative selectivity: The resolution of small peptide sequences can now be enhanced utilising new macrocyclic glycopeptide chiral stationary phases. Chirobiotic mobile phases are generally acetonitrile-water or acetonitrile-buffer based systems that are LC/MS compatible, enabling higher sensitivity than UV detection. More importantly, Chirobiotic phases provide different selectivity, higher resolution and higher capacity when compared to conventional C18, ion pairing and ion exchange methods. Peptides up to 16 amino acids have been separated and current development is underway for peptides to 30 residues in length. Document: Powerpoint presentation Contact:    info@asteceuro.com	Astec
	Ultra High Sensitivity Monitoring of Purification and Trace Impurities with SELDI ProteinChip® Ciphergen Ciphergen's SELDI MS with ProteinChip enhancement technology can be used during Process Development and for Process Monitoring to track separation performance and to assist with Methods Development of any bioproduct, during any step operation including purification with any chromatographic media. Document:  PPS Document Document:  PDF Document E-mail:         breed@ciphergen.com Telephone: +44 (0) 1483 303 011	Ciphergen
	Identification and Removal of Trace Impurities with E-beads™ Technology Ciphergen Ciphergen's E-beads technology for protein equalisation can be used to remove trace impurities from a purified bioproduct, or to extract equimolar quantities of all sample components within a highly purified sample. Subsequent analysis reveals the trace impurity spectrum despite a massive excess of product molar concentration. Document:  PDF Document E-mail:         breed@ciphergen.com Telephone: +44 (0) 1483 303 011	Ciphergen