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Peptide Selectivity Enhanced by Novel Stationary Phase Chemistry Astec Chirobiotic®T for peptide analysis Closely related peptides that are different from each other because of a particular single amino acid or because of the chirality of an amino acid either within the peptide or at its terminus are of great importance in drug discovery. Current LC analysis usually employs reversed phase (C18) methods which often need ion pairing reagents that modify the column and are not MS compatible, or ion exchange LC that uses buffers that are also generally not MS compatible. LC/MS compatibility and improved alternative selectivity: The resolution of small peptide sequences can now be enhanced utilising new macrocyclic glycopeptide chiral stationary phases. Chirobiotic mobile phases are generally acetonitrile-water or acetonitrile-buffer based systems that are LC/MS compatible, enabling higher sensitivity than UV detection. More importantly, Chirobiotic phases provide different selectivity, higher resolution and higher capacity when compared to conventional C18, ion pairing and ion exchange methods. Peptides up to 16 amino acids have been separated and current development is underway for peptides to 30 residues in length. Document: Powerpoint presentation Contact:    info@asteceuro.com

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